Table 1.
Diarrhea in infant rabbits inoculated with the indicated strains
| Straina | C227 | mock | Δstx2 | ΔpAA | Δpic | ΔsigA |
|---|---|---|---|---|---|---|
| Diarrhea (%)b | 73 | 0 | 0 | 71 | 36 | 15 |
|
| ||||||
| Disease category (#)c | ||||||
| Diarrhea | 30 | 0 | 0 | 10 | 5 | 3 |
| Intestinal fluid | 9 | 0 | 2 | 3 | 7 | 10 |
| No gross disease | 2 | 9 | 13 | 1 | 2 | 7 |
|
| ||||||
| Total no. animals | 41 | 9 | 15 | 14 | 14 | 20 |
|
| ||||||
| P-value vs C227d | - | 6.704E-5 | 4.754E-7 | 1 | 0.0223 | 2.37E-5 |
| P-value vs mockd | 6.704E-5 | - | 1 | 1.60E-3 | 0.1157 | 0.5320 |
a
All strains are derivatives of E. coli O104:H4 C227-11 wild type (C227).
b
Percentage of rabbits that exhibited diarrhea by day 3 PI.
c
Number of rabbits within each category as described in the methods.
d
Fisher’s exact test was used to compare the proportion of rabbits with diarrhea in the indicated group vs C227 or mock-infected animals.