Figure 2. Hyperglycemia stimulates fibronectin deposition at sites of disturbed flow in the aortic arch.

The aortic arch was collected from diabetic (6 weeks) and nondiabetic ApoE knockout mice and stained for A) VCAM-1, B) thrombospondin-1, or C) fibronectin deposition. Regions exposed to either laminar flow (greater curvature) or disturbed flow (lesser curvature, carotid branch point) are shown at 20× magnification with 4× magnification inserts of the entire artery. n = 4 – 7 mice per group.