Table 3.
Enrichment of gene groups down-regulated in muscle-less humeri based on GO terms under subontologies biological process and cellular component
| Gene ontology term | Gene count in study | Enrichment 1 | |
|---|---|---|---|
|
Development/Differentiation |
155 |
2.73 × 10-15 to 0.0084 |
|
| |
GO:0048856: Anatomical structure development |
134 |
2.73 × 10-15 |
| GO:0032502: Developmental process |
155 |
1.52 × 10-14 |
|
| GO:0048513: Organ development |
107 |
4.23 × 10-13 |
|
| GO:0007275: Multicellular organismal development |
142 |
4.92 × 10-13 |
|
| GO:0048731: System development |
122 |
5.57 × 10-13 |
|
| GO:0009888: Tissue development |
58 |
8.37 × 10-13 |
|
| GO:0030154: Cell differentiation |
94 |
8.86 × 10-10 |
|
| GO:0048869: Cellular developmental process |
96 |
1.67 × 10-9 |
|
| GO:0048468: Cell development |
45 |
2.66 × 10-7 |
|
| GO:0009887: Organ morphogenesis |
38 |
6.12 × 10-5 |
|
| GO:0001756: Somitogenesis |
8 |
2.61 × 10-4 |
|
| GO:0035282: Segmentation |
9 |
2.66 × 10-4 |
|
| GO:0009952: Anterior/posterior pattern formation |
13 |
0.0033 |
|
| GO:0009790: Embryonic development |
34 |
0.0074 |
|
| GO:0043009: Chordate embryonic development |
24 |
0.0075 |
|
| GO:0009792: Embryonic development ending in birth |
24 |
0.0084 |
|
|
Cytoskeleton |
30 |
5.30 × 10-19 to 0.0995 |
|
| Biological process |
GO:0030029: Actin filament-based process |
25 |
1.45 × 10-9 |
| GO:0030036: Actin cytoskeleton organization |
23 |
1.08 × 10-8 |
|
| GO:0007010: Cytoskeleton organization |
31 |
1.50 × 10-7 |
|
| GO:0007015: Actin filament organization |
5 |
0.0995 |
|
| GO:0015629: Actin cytoskeleton |
39 |
5.30 × 10-19 |
|
| Cellular component |
GO:0005856: Cytoskeleton |
86 |
2.20 × 10-14 |
| GO:0016459: Myosin complex |
21 |
1.26 × 10-15 |
|
| GO:0032982: Myosin filament |
11 |
2.32 × 10-12 |
|
| GO:0044430: Cytoskeletal part |
51 |
1.16 × 10-6 |
|
| GO:0005884: Actin filament |
5 |
0.0134 |
|
|
Cell signalling |
31 |
4.78 × 10-5 to 0.0899 |
|
| GO:0007154: Cell communication |
32 |
4.78 × 10-5 |
|
| GO:0007267: Cell-cell signalling |
23 |
1.33 × 10-4 |
|
| GO:0007169: Transmembrane protein tyrosine kinase signalling |
17 |
3.85 × 10-4 |
|
| GO:0007167: Enzyme linked receptor protein signalling pathway |
20 |
0.0011 |
|
| GO:0008543: Fibroblast growth factor receptor signalling pathway |
5 |
0.0139 |
|
| GO:0045168: Cell-cell signalling involved in cell fate specification |
4 |
0.0271 |
|
| GO:0040036: Regulation of fibroblast growth factor signalling |
3 |
0.0451 |
|
| GO:0043409: Negative regulation of MAPKKK cascade |
3 |
0.0614 |
|
| GO:0007219: Notch signalling pathway | 5 | 0.0899 | |
All GO terms are associated with the subontology “Biological Process” except where indicated under Cytoskeleton, where Cellular Component was also used.
1P-value of enrichment of GO terms using DAVID analysis software; similar results were found with GOstat.