Table 5.

Differentially expressed Wnt signalling pathway genes

Down-regulated Wnt Pathway genes
Fold change		Gene symbol	Gene title	Role in pathway				Reference for role in pathway
RNA-seq	Microarray			Ligand	Receptor	Intra-cellular	Target
#	41.05	Fgf4	Fibroblast growth factor 4				T	[37]
#		Snai3	Snail homolog 3				PT	Snai1 [38]
90.87	32.06	Cacng1	Calcium channel, voltage-dependent, gamma subunit 1				T	[39]
42.86	18.77	Pitx3	Paired-like homeodomain transcription factor 3				PT	Pitx2 [40]
37.43	17.22	Kremen2	Kringle containing transmembrane protein 2		Co-Rec			[41]
29.52		Ccnb3	Cyclin B3				PT	CyclinD1 [42]
12.29	7.05	Rxrg	Retinoid X receptor gamma				PT	Rarg [43]
5.95	5.20	Islr2	Immunoglobulin superfamily containing leucine-rich repeat 2				PT	Islr [44]
4.87		Pitx2	Paired-like homeodomain transcription factor 2				T	[40]
3.58		Fzd10	Frizzled homolog 10		R			[45]
3.16	2.21	Dll1	Delta-like 1				T	[46]
3.05		Prg4	Lubricin				T	[30]
2.81	2.57	Lrrn1	Leucine rich repeat protein 1, neuronal				T	[47]
2.52		Sall1	Sal-like 1				PT	Sall4: [36]
2.47		Tnik	TRAF2 and NCK interacting kinase			TF-act		[48]
2.32		Tcf15	Transcription factor 15				T
2.32		Met	Met proto-oncogene				T	[49]
2.18	2.28	Cd44	CD44 antigen				T	[50]
2.09		Jag2	Jagged2				PT	Jag1 [51]
Up-regulated Wnt pathway genes
4.36	4.91	Grem2	Gremlin				T	[52]
3.96		Wnt2	Wingless-related MMTV integration site 2	L
3.50		Wnt2b	Wingless-related MMTV integration site 2b	L
3.07		Wnt16	Wingless-related MMTV integration site 16	L
2.85	2.90	Kcnd2	Potassium voltage-gated channel, shal-related family, member 2				T	[47]
2.73		Cldn1	Claudin-1				T	[53]
2.44		Dkk2	Dickkopf	Ant			T	[47,54]
2.43	3.08	Rspo2	R-spondin 2	L			T	[47,55,56]
2.37		Epha4	Eph receptor A4				T	[47]
2.11		Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2				T	[47]
2.10		Cpz	Carboxypeptidase Z	Co-act				[33]
2.09	2.62	Sfrp2	Secreted frizzled related protein 2	Ant			T	[57]
2.03		Wnt4	Wingless-related MMTV integration site 4	L
2.02		Rspo3	R-spondin 3	L			T	[47,58]
	2.41	E330013P04Rik	RIKEN cDNA E330013P04 gene				T	[47]

#No numerical value for fold change as no transcripts detected in the Mutant.

T -Target, PT -Potential Target, R -Receptor, Co-Rec -Co-Receptor, TF-act -Transcription Factor activator, L -Ligand, Ant -Antagonist, Co-act -Co-activator.