Figure 1.

Dosimetry and short term retention of TiO₂ for single high dose TiO₂ exposure. The mass of TiO₂ deposited in the lung following whole body inhalation (blue squares) and intratracheal instillation (green circles) was determined immediately, 24 hr and 7 days post exposure (A) and the compartmentalization of TiO₂ in BALF supernatant, BALF cell pellet and the remaining lung tissue after lavage (lavaged lung) were determined 24 hr post exposure (B). Values are group means (n = 3–5) ± standard error (SE). The inhalation and instillation ILBs were not found to be significantly different; *, significantly different compared to the respective ILB (p < 0.05).