Fig. 1.

Pazopanib has single-agent in vitro antineoplastic activity in ATC. (A) Chemical structure of pazopanib. (B and C) Growth-inhibitory effects of pazopanib (continuous drug exposures) in three ATC cell lines (B) and in four patient primary low-passage ATC cell culture models (C). In (B) and (C), results of representative colony-forming assays are shown (each data point indicates the mean of triplicate results; error bars indicate 1 sample SD). (D) Summary data indicating IC₅₀ mean and SD values for each cell line/culture compared to three DTC cell lines [all results reflect more than three replicate experiments as shown in (B) and (C)].