Table IV.
Grade 3+ toxicity (adverse events considered at least possibly related to R-DHAP) was observed in 98% (56/57) of patients.
| Toxicity type | Grade 3 (%) | Grade 4 (%) | Grade 5 (%) |
|---|---|---|---|
| General | |||
| Fatigue | 6 (11) | 1 (2) | |
| Hematological | |||
| Anemia | 12 (21) | 1 (2) | |
| Neutropenia | 6 (11) | 39 (68) | |
| Thrombocytopenia | 30 (53) | 22 (39) | |
| Infection | |||
| Infection without neutropenia | 1 (2) | ||
| Infection with neutropenia | 2 (4) | 1 (2) | |
| Febrile neutropenia | 12 (21) | 1 (2) | |
| Gastrointestinal | |||
| Anorexia | 3 (5) | ||
| Nausea | 10 (18) | ||
| Vomiting | 6 (11) | 1 (2) | |
| Diarrhea | 3 (5) | 1 (2) | |
| Metabolic | |||
| Hypokalemia | 13 (23) | ||
| Hypomagnesemia | 1 (2) | 1 (2) | |
| Creatinine | 4 (7) | ||
| Renal failure | 2 (4) | ||
| Maximum overall toxicity grade | 13 (23) | 42 (25) | 1 (2) |
Maximal overall toxicity grade refers to the number of patients that had the respective grade toxicity across all toxicity types.