Adropin knockout mice (KO) weaned onto standard rodent chow exhibit increased adiposity at 9 weeks, but not 6 weeks of age. (a, b) Body weight and adiposity (fat mass as a percent of total body weight) (c, d) are shown for male and female mice at (a, c) 6 weeks and (b, d) 9 weeks of age. At 9 weeks of age, male and female knockout mice exhibit increased fat mass and adiposity; there was no significant difference in any of the parameter measured in heterozygous carriers of the null allele (HET). *P < 0.05 vs. WT. n = 3–5 per group.