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. Author manuscript; available in PMC: 2014 Jan 29.
Published in final edited form as: Obesity (Silver Spring). 2012 Feb 9;20(7):1394–1402. doi: 10.1038/oby.2012.31

Figure 6.

Figure 6

Increased hepatic lipid content and expression of lipogenic genes in adropin knockout mice (AdrKO)-fed high-fat diet (HFD). (a) Total lipid and triglyceride (TG) content (per g wet weight) of liver samples collected from fasted wild type (WT), heterozygous (HET), and homozygous carriers (KO) of the null adropin allele. *P < 0.05 vs. WT. (b) Histological analysis of the liver phenotye of WT mice with AdrKO fed HFD. (c) Expression of genes involved in lipid and carbohydrate metabolism in livers of WT, HET, and KO mice. The expression of stearoyl-CoA desaturase-1 (SCD1) and sterol-regulatory element-binding protein-1c (SREBP1C) was significantly affected by genotype. ACC1, acetyl-CoA carboxylase; CPT1, carnitine palmitoyl transferase-1; FAS, fatty acid synthase; G6p, glucose-6-phosphatase; LPL, lipoprotein lipase; PEPCK, phosphoenolpyruvate carboxykinase; PPARα, peroxisome proliferator- activated receptor α.