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. Author manuscript; available in PMC: 2015 Jan 3.
Published in final edited form as: Chembiochem. 2013 Nov 29;15(1):157–169. doi: 10.1002/cbic.201300565

Figure 1. Design Strategy.

Figure 1

A) Schematic structure of mouse P-gp crystal structure bound to QZ59Se-SSS,[5] chemical structures of QZ59Se-SSS and Valspodar, B) Human P-gp homology model generated from mouse P-gp (PDB ID: 3G60), cyclic trimer (QZ59S-SSS) and cyclic hexamer.