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BM and splenic CXCL12 secretion. Unfractionated BM and splenic cells from a total of 12 control mice and 8 infected mice per timepoint were incubated in media for 48 hours and secreted CXCL12 was measured via ELISA. BM CXCL12 production (A) was significantly decreased at days 2-8 post-infection. Splenic CXCL12 production (B) was significantly increased at day 6 post-infection (asterisk = p<.05, bars = standard error).
