Table 2.
The association analysis between SNPs in PPAR-α/γ and dyslipidemia
| SNP | Model | Genotype | Non- dyslipidemia(N = 628) | Dyslipidemia(N = 192) | OR (95%CI) | P |
|---|---|---|---|---|---|---|
| rs1800206 |
|
|
|
|
|
|
| |
Codominant |
LL |
524 |
98 |
1.0 |
<0.001 |
| |
|
LV |
99 |
92 |
5.75 (3.91-8.46) |
|
| |
|
VV |
5 |
2 |
2.38 (0.43-13.31) |
|
| |
Log additive |
- |
- |
- |
4.74 (3.29-6.84) |
<0.001 |
| rs4253778 |
|
|
|
|
|
|
| |
Codominant |
CC |
469 |
146 |
1.0 |
0.670 |
| |
|
CG |
133 |
41 |
0.95 (0.63-1.43) |
|
| |
|
GG |
26 |
5 |
0.65 (0.24-1.78) |
|
| |
Log additive |
- |
- |
- |
0.89 (0.64-1.23) |
0.470 |
| rs3856806 |
|
|
|
|
|
|
| |
Codominant |
CC |
343 |
75 |
1.0 |
0.005 |
| |
|
CT |
237 |
89 |
1.58 (1.09-2.27) |
|
| |
|
TT |
48 |
28 |
2.23 (1.28-3.90) |
|
| |
Log additive |
- |
- |
- |
1.53 (1.19-1.97) |
<0.001 |
| rs1805192 |
|
|
|
|
|
|
| |
Codominant |
ProPro |
380 |
79 |
1.0 |
<0.001 |
| |
|
ProAla |
206 |
82 |
1.77 (1.22-2.56) |
|
| |
|
AlaAla |
42 |
31 |
2.96 (1.70-5.14) |
|
| Log additive | - | - | - | 1.76 (1.36-2.27) | <0.001 |
Adjusted for gender, age, smoke, alcohol, body mass index and waist circumference.