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. 2014 Jan;14(1):69–95. doi: 10.2174/15665240113136660079

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© 2013 Bentham Science Publishers

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. (13) — Diagnostic features of epidermolysis bullosa acquisita (EBA). (a) Clinical picture of a 61-year old female patient with the inflammatory form of EBA showing erythema, tense blisters, erosions and crusts on the lateral abdomen. (b) Histopathology analysis of the lesional skin shows dermal-epidermal separation and a neutrophil-rich inflammatory infiltrate. (c) Direct immunofluorescence microscopy of perilesional skin reveals deposits of IgG along the basement membrane zone. (d) Indirect immunofluorescence microscopy on 1M NaCl split-skin shows binding of IgG autoantibodies to the dermal side of the dermal-epidermal junction (magnification 200x).