Table 10.

Diagnostic Criteria for Bullous Pemphigoid

Investigation	Finding
Clinic	Tense blisters, erythematous plaques, pruritic papules.
Histology	Sub-epidermal blister with a inflammatory infiltrate consisting predominantly of eosinophils and neutrophils
Direct immunofluorescence microscopy	Linear C3 and IgG deposits at the dermo-epidermal junction
Indirect immunofluorescence microscopy on salt-split-skin	Binding of IgG autoantibodies to the epidermal side
ELISA / Immunoblot	BP180- and/or BP230-specific IgG autoantibodies