Table 12.

Diagnostic Criteria for Linear IgA Disease

Investigation	Finding
Clinic	Polymorphic picture with erythema, blisters, erosions on skin and mucosa
Histology	Subepidermal blisters, neutrophils accumulating at the papillary tips
Direct immunofluorescence microscopy	Linear IgA deposits at the dermo-epidermal junction
Indirect immunofluorescence microscopy (salt-split-skin)	Binding of IgA autoantibodies to the epidermal side
ELISA / Immunoblot	IgA against the shed ectodomain of BP180 (LAD-1)