Table 2.
Quantitative Immunoassays for the Detection of Autoantibodies in Autoimmune Blistering Skin Diseases
| Autoantigen | Epitope(s) | Disease(s) | Commercially Available |
References |
|---|---|---|---|---|
| Desmoglein 1 | Ectodomain | Pemphigus | yes | [26, 178] |
| Desmoglein 3 | Ectodomain | Pemphigus | yes | [26, 178] |
| Envoplakin | Full-length | Paraneoplastic pemphigus | yes | [179-181] |
| Periplakin | Full-length | Paraneoplastic pemphigus | no | [179, 180] |
| BP180/collagen XVII | NC16A domain | Pemphigoid (IgG, IgE) | yes | [92, 95, 182-184] |
| 4xNC16A domain | Pemphigoid (IgG) | yes | [62] | |
| Ectodomain | Pemphigoid (IgA) | no | [138] | |
| BP230 | Fragments covering the full-lenght of BP230 | Pemphigoid (IgG) | yes | [93] |
| Laminin Γ1 (p200) | C-terminal regiÓn | Anti-p200 pemphigoid (IgG) | no | [150] |
| Collagen VII | NC1 domain | Epidermolysis bullosa acquisita (IgG) | yes | [185, 186] |
| NC1, NC2 domains | Epidermolysis bullosa acquisita (IgG) | yes | [159] | |
| NC1, NC2, hinge domains | Epidermolysis bullosa acquisita (IgG) | no | [161] | |
| Transglutaminase, tissue |
Full-length | Dermatitis herpetiformis (IgA) | yes | [166, 187] |
| Transglutaminase, tissue |
Deamidated gliadin-analogous fusion peptides | Dermatitis herpetiformis (IgA) | yes | [188] |
| Transglutaminase, epidermal |
Dermatitis herpetiformis (IgA) | yes | [167] |