Figure 6. In silico analysis of region immediately surrounding top GWAS SNP rs11098403.

An H3K4me1 activation mark at this locus is observed in H1 human embryonic cell lines (grey arrow). A close proxy SNP (rs17862077, which is 2,953 bp telomeric to rs11098403; r²=0.96 in 1,000 Genomes CEU), neighbours an unmethylated CpG island (red arrow), which is the only such site within an 850-kb intergenic window. Additional SNPs with the same LD relationship to rs11098403 (for example, rs11562906) localize to an H3K4me1 mark detected in hippocampus (blue arrow).