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. Author manuscript; available in PMC: 2014 Dec 23.
Published in final edited form as: Biochemistry. 2013 Nov 26;52(51):9286–9293. doi: 10.1021/bi4013319

Figure 7.

Figure 7

“Global Simulation of Mass Spectrometry Data” The Model shown in Scheme 2 was used as was the KinTek Global Kinetic Explorer (Ver. 3.0.2362). Isotopic species are: all protio isocitrate (red), all protio succinate (blue), mono-deutero isocitrate (green), mono-deuterated succinate (yellow) and di-deutero succinate (light blue). The rate constants yielding the curves through the experimental points are: k1 = 9.53 × 10−5 s−1; k−1 = 2.33 x10−4 s−1; k2 = 3.83 × 10−4 s−1; k−2 = 2.83 × 10−4 s−1; k3 = 3.43 × 10−5 s−1; k−3 = 4.05 × 10−5 s−1; k4 = 3.83 × 10−5 s−1; k−4 = 2.83 × 10−4 s−1.