Figure 13.

Model of promoter RNA-mediated activation of COX-2 and PLA2G4A genes. (A) Ground state: promoter RNAs are expressed at the COX-2 promoter. COX-2 and PLA2G4A are expressed at low levels. (B) Intermediate state: The sense promoter RNA is a platform for recognition by a small complementary RNA (endogenous or synthetic) and recruitment of AGO2 and GW182. (C) Gene activation state: Binding of small RNA/AGO2/GW182 complex leads to association of transcription factors and WDR5, and an increase in activating histone marks. Specific gene looping is induced between the COX-2 and PLA2G4A promoters, enabling activations of both genes.