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The COX-2 promoter RNA contains two binding sites for miR-589-5p. (A) Binding sites for miR-452 and miR-589-5p relative to the COX-2 promoter. (B) The two target sites for miR-589-5p within the sense COX-2 promoter RNA. Bold and underlined: seed sequences. (C) Sequence conservation of binding sites for miR-589-5p in primates. Underlined: seed sequences.
