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. 2013 Sep 5;41(22):10476–10487. doi: 10.1093/nar/gkt799

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Scheme 1. — Synthesis of ^SeU-phosphoramidite (3) and ^SeU-RNAs (4). Reagents and conditions: (a) TIBS-Cl, 4,4′-dimethylamino-pyridine, CH₂Cl₂, room temperature; (b) (NCCH₂CH₂Se)₂/NaBH₄, EtOH; (c) 2-cyanoethyl N,N-diisopropylchloro-phosphoramidite and N,N-diisopropylethylamine in CH₂Cl₂; (d) the solid-phase synthesis. TIBS-Cl: 2,4,6-(triisopropylbenzene)sulfonyl chloride.