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. 2013 Sep 7;41(22):10641–10658. doi: 10.1093/nar/gkt801

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — (A) Predictions of IEL () for different values of the sawtooth amplitude and plateau height . needs to be as high as 7.3 kcal/mol (>4 base-pair stacks) to match experiment (30). (B) Contour plot of orders of magnitude acceleration () as a function of () for kcal/mol and kcal/mol. (C) Scatter plot of versus using all the data in (B). The points plotted show almost no vertical spread, meaning that all points lie on a line. This indicates that is the predictive quantity. Inset: IEL (1.3, 0) and IEL (5.0, 5.0) for a 1-base toehold. The bimolecular initial binding step, which is identical in both landscapes, is marked in orange to highlight the contrast between the landscapes.

Inline graphic — (A) Predictions of IEL () for different values of the sawtooth amplitude and plateau height . needs to be as high as 7.3 kcal/mol (>4 base-pair stacks) to match experiment (30). (B) Contour plot of orders of magnitude acceleration () as a function of () for kcal/mol and kcal/mol. (C) Scatter plot of versus using all the data in (B). The points plotted show almost no vertical spread, meaning that all points lie on a line. This indicates that is the predictive quantity. Inset: IEL (1.3, 0) and IEL (5.0, 5.0) for a 1-base toehold. The bimolecular initial binding step, which is identical in both landscapes, is marked in orange to highlight the contrast between the landscapes.