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. 2013 Sep 17;41(22):10228–10240. doi: 10.1093/nar/gkt827

Figure 1.

Figure 1.

Expression profiling shows that LRH-1 regulates the expression of oestrogen-regulated genes. (A) Western blot analysis of MCF-7 cell extracts prepared following transfection with control siRNA or four independent siRNAs for LRH-1. (B) Quantitative RT-PCR analysis was performed using three independent RNA preparations made from siControl– or siLRH-1–transfected MCF-7 cells. Error bars represent standard errors of the mean (SEM). (C) Gene expression profiling was carried out using four independent replicates of MCF-7 cells transfected with siControl, siLRH-1 #2 or siLRH-1 #3. Shown are significant differentially expressed genes at P < 0.01 corrected for false discovery rate (FDR), together with a fold change >1.5 and <−1.5. (D) GO category enrichments of the genes differentially regulated by siLRH-1 are shown.