Table 4.
Summary of significant sex-diagnosis interactions of serum molecules measured by LC-MS E profiling
| |
|
|
|
Males |
Females |
||
|---|---|---|---|---|---|---|---|
| Code | Protein | Interaction | FDR | Ratio | P -value | Ratio | P -value |
| RGPD4 |
RANBP2-like and GRIP domain containing 5 |
0.015 |
0.723 |
0.89 |
0.016 |
1.07 |
0.893 |
| ARMC3 |
Armadillo repeat containing 3 |
0.002 |
0.291 |
0.88 |
0.183 |
1.29 |
0.001 |
| PTPA |
PP 2A activator, reg subunit 4 |
0.038 |
0.723 |
0.97 |
0.681 |
1.23 |
0.001 |
| TLE1 |
Transducin-like enhancer of split 1 |
0.049 |
0.723 |
0.90 |
0.394 |
1.22 |
0.026 |
| CLC4K |
CD207 molecule, langerin |
0.017 |
0.723 |
0.96 |
0.720 |
1.20 |
<0.001 |
| GLCE |
Glucuronic acid epimerase |
0.017 |
0.723 |
0.88 |
0.231 |
1.19 |
0.018 |
| APOC2 |
Apolipoprotein C2 |
0.005 |
0.522 |
0.92 |
0.254 |
1.19 |
0.001 |
| ZC3HE |
Zinc finger CCCH-type containing 14 |
0.039 |
0.723 |
0.97 |
0.383 |
1.16 |
0.020 |
| FETUB |
Fetuin B |
0.035 |
0.723 |
0.96 |
0.572 |
1.15 |
0.004 |
| RN149 |
Ring finger protein 149 |
0.044 |
0.723 |
1.02 |
0.588 |
1.14 |
0.042 |
| TRIPB |
Thyroid hormone receptor interactor 11 |
0.012 |
0.723 |
0.94 |
0.610 |
1.13 |
0.027 |
| APOE |
Apolipoprotein E |
0.030 |
0.723 |
0.99 |
0.851 |
1.11 |
<0.001 |
| MRRP1 | RNA G9 methyltransferase domain cont 1 | 0.044 | 0.723 | 1.06 | 0.592 | 0.78 | 0.035 |
Indicated are the P-values and FDR (false discovery rate) of the interactions and the separate ratio (AS/control; calculated using geometric means) changes with P-values in males in females. Values in bold font indicate significant differences between AS and typical individuals by sex.