Table 2.
Biological process of altered genes identified by MLPA in pediatric glioma and of neighbour genes located in the critical deleted regions
| Gene | Biological process | Chromosomal region | Neighbor genes | Biological process |
|---|---|---|---|---|
|
TNFRSF4 |
Inflammatory and immune response |
01p36 |
TNFRSF18 |
Apoptosis |
| |
|
|
TTLL10 |
Protein polyglycylation |
| |
|
|
SDF4 |
UV protection |
|
TP73 |
DNA damage response |
01p36.3 |
ARHGEF16 |
Apoptosis |
| |
|
|
LRRC47 |
Translation |
| |
|
|
SMIM1 |
|
| |
|
|
WRAP73 |
|
| |
|
|
TPRG1L |
Synapse |
| |
|
|
MEGF6 |
Calcium ion binding |
|
PPAP2B |
Blood vessel development |
01pter-p22.1 |
PRKAA2 |
Protein phosphorylation |
| |
|
|
C1orf168 |
|
|
DPYD |
Purine base catabolic process |
01p22 |
PTBP2 |
mRNA processing |
|
PDCD5 |
Apoptosis |
19q12-q13.1 |
ANKRD27 |
Early endosome to late endosome transport |
| |
|
|
DPY19L3 |
|
| |
|
|
CEP89 |
|
| |
|
|
SLC7A9 |
Protein complex assembly |
| |
|
|
TDRD12 |
|
| |
|
|
NUDT19 |
|
| |
|
|
RGS9BP |
Negative regulation of signal transduction |
|
BAX |
Apoptosis |
19q13.3-q13.4 |
FTOL |
|
| |
|
|
NTN5 |
|
| |
|
|
PP1R15A |
Apoptosis |
| |
|
|
NUCB1 |
|
| |
|
|
CD37 |
Regulation of humoral immune response |
| |
|
|
PPFIA3 |
Neurotransmitter secretion |
| |
|
|
CGB |
|
| |
|
|
TYS1 |
Apoptosis |
| DHDH |
Only the most nearby protein-coding genes were selected.