Table 5.
Odds ratios and 95% confidence intervals for high levels of serum non-HDL cholesterol by Mt5178 C/A genotype and drinking status
| Genotype and alcohol consumption |
Frequency |
OR (95% CI) | Adjusted OR † (95% CI) | Adjusted OR ‡ (95% CI) | |
|---|---|---|---|---|---|
| Normal levels of serum non-HDL cholesterol | High levels of serum non-HDL cholesterol | ||||
| |
non-HDL cholesterol <160 mg/dl |
non-HDL cholesterol ≥160 mg/dl |
|
|
|
| Mt5178C |
|
|
|
|
|
| Non- or ex-drinkers |
22 (50.0) |
22 (50.0) |
1 (reference) |
1 (reference) |
1 (reference) |
| Occasional drinkers |
55 (65.5) |
29 (34.5) |
0.527 (0.251-1.108) |
0.430 (0.194-0.953)* |
0.439 (0.190-1.016) |
| Daily drinkers |
80 (72.1) |
31 (27.9) |
0.388 (0.188-0.798)* |
0.308 (0.142-0.665)** |
0.312 (0.139-0.698)** |
| |
|
|
P for trend = 0.012 |
P for trend = 0.005 |
P for trend = 0.005 |
| Mt5178A |
|
|
|
|
|
| Non- or ex-drinkers |
17 (81.0) |
4 (19.0) |
1 (reference) |
1 (reference) |
1 (reference) |
| Occasional drinkers |
38 (63.3) |
22 (36.7) |
2.461 (0.734-8.244) |
2.491 (0.720-8.619) |
2.499 (0.649-9.618) |
| Daily drinkers |
48 (64.9) |
26 (35.1) |
2.302 (0.701-7.561) |
2.022 (0.595-6.875) |
2.114 (0.583-7.665) |
| |
|
|
P for trend = 0.310 |
P for trend = 0.385 |
P for trend = 0.348 |
| |
non-HDL cholesterol <190 mg/dl |
non-HDL cholesterol ≥190 mg/dl |
|
|
|
| Mt5178C |
|
|
|
|
|
| Non- or ex-drinkers |
36 (81.5) |
8 (18.2) |
1 (reference) |
1 (reference) |
1 (reference) |
| Occasional drinkers |
74 (88.1) |
10 (11.9) |
0.608 (0.221-1.672) |
0.627 (0.221-1.780) |
0.858 (0.279-2.640) |
| Daily drinkers |
100 (90.1) |
11 (9.9) |
0.495 (0.184-1.328) |
0.408 (0.146-1.139) |
0.330 (0.108-1.003) |
| |
|
|
P for trend = 0.181 |
P for trend = 0.140 |
P for trend = 0.123 |
| Mt5178A |
|
|
|
|
|
| Non- or ex-drinkers |
19 (90.5) |
2 (9.5) |
1 (reference) |
1 (reference) |
1 (reference) |
| Occasional drinkers |
54 (90.0) |
6 (10.0) |
1.056 (0.196-5.684) |
1.014 (0.176-5.853) |
0.938 (0.154-5.714) |
| Daily drinkers |
64 (86.5) |
10 (13.5) |
1.484 (0.299-7.368) |
1.190 (0.230-6.156) |
1.325 (0.219-7.996) |
| P for trend = 0.513 | P for trend = 0.605 | P for trend = 0.560 | |||
†OR adjusted for age and body mass index. ‡OR adjusted for age, body mass index, cigarette smoking, coffee consumption and antihypertensive medication. *P < 0.05, **P < 0.005. CI, confidence interval; HDL, high-density lipoprotein; Mt5178C, mitochondrial DNA 5178 cytosine; Mt5178A, mitochondrial DNA 5178 adenosine; OR, odds ratio.