Table 3. Rates of myocardial infarction per 1,000 persons per year (PY) in men under age 65 years and those age 65 years and older, in pre- and post-prescription intervals for an initial prescription for PDE5I with adjusted^* rate ratios (RR), and 95% confidence intervals (CI).

	All Ages	Age <65Years	Age ≥65Years
Patients (N)	167,279†	141,512†	25,767†
Pre-prescription
Cases	695	556	139
Rate per 1,000 PY (95%CI)	3.48 (3.02, 4.01)	3.22 (2.75, 3.77)	5.27 (3.81, 7.27)
Post-prescription
Cases	152	119	33
Rate per 1,000 PY (95%CI)	3.75 (3.19, 4.40)	3.42 (2.76, 4.24)	6.06 (4.26, 8.63)
Rate Ratio (post/pre) (95%CI)	1.08 (0.93, 1.24)	1.06 (0.91, 1.24)	1.15 (0.83, 1.59)

^*Adjusted for age and pre-existing medical conditions and medication use associated with MI or its risk factors (Table 1 and Supplemental Tables).

^†Effective sample sizes of PDE5I cohorts after weighting:

All Ages: 141,671.

Age <65: Years 121,696.

Age ≥65: Years 19,505.