Table 4. Rates of myocardial infarction in men under and 65 and those 65 and older per 1,000(PY) in pre- and post-prescription intervals for an initial prescription for TT or PDE5 inhibitors, with adjusted^* rate ratios (RR), ratio of rate ratios (RRR) and 95% confidence limits (CL) by history of heart disease.

	Heart Disease History		No Heart Disease History
	TT Prescription	PDE5I	TT Prescription	PDE5I
Age <65 Years
Patients (N)	4,006	10,681†	44,533	130,831†
Pre-prescription
Cases	21	65	135	491
Rate per 1,000 PY (95%CI)	5.26 (3.43, 8.06)	5.26 (3.43, 8.06)	3.04 (2.57, 3.60)	3.04 (2.57, 3.60)
Post-prescription
Cases	15	20	30	99
Rate per 1,000 PY (95%CI)	15.22 (9.18, 25.25)	7.34 (6.89, 7.82)	2.73 (1.91, 3.91)	3.01 (2.95, 3.08)
Rate Ratio (post/pre) (95%CI)	2.9 (1.49, 5.62)	1.4 (0.91, 2.14)	0.90 (0.61, 1.34)	0.99 (0.84, 1.17)
RRR‡ (95%CI)	2.07 (1.05, 4.11)		0.91 (0.60, 1.37)
Age ≥65 Years
Patients (N)	2,047	5,492†	5,057	20,275†
Pre-prescription
Cases	15	35	22	104
Rate per 1,000 PY (95%CI)	7.36 (4.44, 12.22)	7.36 (4.44, 12.22)	4.41 (2.90, 6.7)	4.41 (2.90, 6.7)
Post-prescription
Cases	8	13	12	20
Rate per 1,000 PY (95%CI)	15.91 (7.96, 31.81)	8.35 (7.36, 9.48)	9.74 (5.53, 17.14)	4.04 (3.69, 4.42)
Rate Ratio (post/pre) (95%CI)	2.16 (0.92, 5.10)	1.13 (0.68, 1.88)	2.21 (1.09, 4.46)	0.92 (0.60, 1.39)
RRR‡ (95%CI)	1.90 (0.66, 5.50)		2.41 (1.12, 5.17)
Under 65 with heartdisease history	9,003
Under 65 without a history of heart disease	112,588
65 and older with heart disease history	4,190
65 and older without a history ofheart disease	15,718
‡ RRR = RR TT cohort/RR PDE5I cohort

^*Adjusted for age and pre-existing medical conditions and medication use associated with MI or its risk factors.

^†Effective sample size of PDE5 inhibitor cohort after weighting.

Under 65 with heart disease history: 9,003.

Under 65 without a history of heart disease: 112,588.

65 and older with heart disease history: 4,190.

65 and older without a history of heart disease: 15,718.

^‡RRR = RR TT cohort/RR PDE5I cohort.