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. 2014 Jan 29;9(1):e86391. doi: 10.1371/journal.pone.0086391

Figure 6. Effects of THS-exposure on behavior of mice.

Figure 6

(A,B) Testing for anxiety. Control and THS mice were tested using an Elevated Plus T-maze (Fig. S1A). (A) Total time spent in the open and closed arms was measured. The two groups both spent much more time in closed than in open arms of the maze, indicating normal anxious behavior. (B) The frequency of entries into the closed arms was significantly greater for THS-exposed as compared to control mice, indicating more locomotor activity. n = 6 controls and 6 THS-exposed mice. (C,D) Testing for hyperactivity. The Open Field test (Fig. S1B) was used to perform these experiments. The behavior of control and THS-exposed mice was observed for 1 hr. (C) The THS mice spent much more time walking, much less time stationary, and more time rearing than the controls. (D) The same general pattern was observed for the frequency of transition between these behaviors; n = 12 controls and 12 THS-exposed mice.