Table 2.
Relative odds of lower than median values of quality of life scores at baseline by categories of social integration in the Pathways study (N=3,139)
| Socially integrated |
Moderately integrated |
Socially isolated | p-value | |
|---|---|---|---|---|
| N (%) | 1,462 (46.5) | 1,219 (38.8) | 482 (15.1) | |
| Functional Assessment Cancer Therapy- General (Fact-G) |
633 | 642 | 298 | |
| Age-adjusted | 1.00 | 1.47 | 2.59 | <0.001 |
| 95% CI | (1.26-1.71) | (2.08-3.24) | ||
| Multivariate-adjusted I* | 1.00 | 1.44 | 2.31 | <0.001 |
| 95% CI | (1.22-1.69) | (1.82-2.93) | ||
| Multivariate-adjusted II † | 1.00 | 1.11 | 1.27 | 0.03 |
| 95% CI | (0.94-1.32) | (0.98-1.65) | ||
| Functional Assessment Cancer Therapy- Breast (Fact-B) |
622 | 651 | 287 | |
| Age-adjusted | 1.00 | 1.57 | 2.43 | <0.001 |
| 95% CI | (1.34-1.83) | (1.95-3.04) | ||
| Multivariate-adjusted I* | 1.00 | 1.54 | 2.18 | <0.001 |
| 95% CI | (1.11-1.82) | (1.72-2.77) | ||
| Multivariate-adjusted II † | 1.00 | 1.21 | 1.21 | 0.01 |
| 95% CI | (1.02-1.45) | (0.93-1.57) | ||
| Trial Outcome Index- Physical/Functional/Breast (TOI-PFB) |
630 | 603 | 272 | |
| Age-adjusted | 1.00 | 1.30 | 2.07 | <0.001 |
| 95% CI | (1.11-1.52) | (1.66-2.59) | ||
| Multivariate-adjusted I* | 1.30 | 1.94 | <0.001 | |
| 95% CI | (1.10-1.54) | (1.53-2.46) | ||
| Multivariate-adjusted II † | 1.00 | 1.08 | 1.26 | 0.05 |
| 95% CI | (0.91-1.29) | (0.98-1.63) | ||
| Breast Cancer Symptoms (BCS) | 650 | 610 | 248 | |
| Age-adjusted | 1.00 | 1.25 | 1.55 | <0.001 |
| 95% CI | (1.07-1.46) | (1.25-1.92) | ||
| Multivariate-adjusted I* | 1.00 | 1.26 | 1.48 | <0.001 |
| 95% CI | (1.07-1.48) | (1.18-1.87) | ||
| Multivariate-adjusted II † | 1.00 | 1.09 | 1.03 | 0.09 |
| 95% CI | (0.92-1.29) | (0.81-1.32) | ||
| Physical Well-Being (PWB) | 679 | 601 | 267 | |
| Age-adjusted | 1.00 | 1.11 | 1.69 | <0.001 |
| 95% CI | (0.95-1.30) | (1.36-2.10) | ||
| Multivariate-adjusted I* | 1.00 | 1.11 | 1.61 | <0.001 |
| 95% CI | (0.94-1.31) | (1.27-2.03) | ||
| Multivariate-adjusted II † | 1.00 | 0.99 | 1.24 | 0.31 |
| 95% CI | (0.84-1.17) | (0.97-1.59) | ||
| Social Well-Being (SWB) | 510 | 651 | 315 | |
| Age-adjusted | 1.00 | 2.15 | 4.09 | <0.001 |
| 95% CI | (1.84-2.52) | (3.37-5.13) | ||
| Multivariate-adjusted I* | 1.00 | 2.02 | 3.46 | <0.001 |
| 95% CI | (1.72-2.37) | (2.73-4.39) | ||
| Multivariate-adjusted II † | 1.00 | 1.49 | 1.76 | <0.001 |
| 95% CI | (1.25-1.77) | (1.35-2.30) | ||
| Emotional Well-Being (EWB) | 621 | 599 | 248 | |
| Age-adjusted | 1.00 | 1.32 | 1.72 | <0.001 |
| 95% CI | (1.13-1.55) | (1.39-2.14) | ||
| Multivariate-adjusted I* | 1.00 | 1.34 | 1.67 | <0.001 |
| 95% CI | (1.14-1.58) | (1.33-2.11) | ||
| Multivariate-adjusted II † | 1.00 | 1.13 | 1.11 | 0.08 |
| 95% CI | (0.95-1.34) | (0.87-1.43) | ||
| Functional Well-Being (FWB) | 577 | 599 | 270 | |
| Age-adjusted | 1.00 | 1.49 | 2.30 | <0.001 |
| 95% CI | (1.27-1.74) | (1.85-2.86) | ||
| Multivariate-adjusted I* | 1.00 | 1.48 | 2.08 | <0.001 |
| 95% CI | (1.26-1.74) | (1.65-2.62) | ||
| Multivariate-adjusted II † | 1.00 | 1.18 | 1.19 | 0.05 |
| 95% CI | (0.99-1.40) | (0.92-1.53) |
p-value, continuous variable
Multivariate-adjusted I models adjusted for age (continuous), time between diagnosis and study entry, race/ethnicity (White (ref), African-American, Hispanic, Asian, other), education (<HS, HS, <college, college degree or greater), income (<$25K, $25-<$70K, $70K+(ref)), stage (I (ref), II, III, IV), estrogen receptor status (positive, negative (ref)), nodal status (positive, negative (ref)), surgery type (mastectomy (ref), lumpectomy, other), chemotherapy (yes, no (ref)), hormonal treatment (yes, no (ref)), radiation (yes, no (ref)), menopausal status (postmenopausal, premenopausal (ref)), parity (0, 1-2, 3 or more), comorbidity (any comorbidity defined by Charlson index, no (ref)), body mass index (BMI<25 (ref), 25-<30, 30+ kg/m2), smoking (never (ref), past, current), physical activity (quartiles, Q1=ref).
MV-adjusted model 2 is adjusted additionally for social support mechanisms