Table 2. Association between BRCA1 or BRCA2 mutation status and mean relative TL in the IMPACT study, adjusting for age and smoking status, and in the RMH Carrier Clinic Set, adjusting for age.
| Cohort | Genetic status | n | Adjusted Mean rel TL (se) | P vs non-carriers |
| IMPACT set | BRCA1/2 Non-carrier | 214 | 1.17 (0.024) | - |
| BRCA1 Carriers | 240 | 1.16 (0.226) | 0.638 | |
| BRCA2 Carriers | 207 | 1.19 (0.024) | 0.768 | |
| All BRCA1&2 Carriers | 447 | 1.17 (0.017) | 0.900 | |
| RMH Carrier Clinic Set (all samples) | BRCA1/2 Non-carrier | 43 | 1.69 (0.082) | - |
| BRCA1 Carriers | 131 | 1.69 (0.041) | 0.969 | |
| BRCA2 Carriers | 110 | 1.65 (0.043) | 0.653 | |
| All BRCA1&2 Carriers | 241 | 1.67 (0.030) | 0.815 | |
| RMH Carrier Clinic Set (unaffected only) | BRCA1/2 Non-carrier | 43 | 1.72 (0.079) | - |
| BRCA1 Carriers | 65 | 1.70 (0.049) | 0.809 | |
| BRCA2 Carriers | 50 | 1.76 (0.049) | 0.746 | |
| All BRCA1&2 Carriers | 115 | 1.72 (0.037) | 0.987 |