Figure 2. Distribution of treatment step* according to GINA classification in subjects with controlled asthma, partially controlled asthma and uncontrolled asthma, at follow-up.

* STEP 1: As needed short-acting β₂-agonist; STEP 2: Sustained release theophylline OR Leukotriene modifier OR Low-dose Inhaled Corticosteroids (ICS); STEP 3: Low-dose ICS plus long-acting β₂-agonist OR Low-dose ICS plus leukotriene modifier OR Low-dose ICS plus sustained release theophylline OR Medium or high dose ICS; STEP 4: Medium or high dose ICS plus long-acting β₂-agonist OR Medium or high dose ICS plus leukotriene modifier OR Medium or high dose ICS plus sustained release theophylline; STEP 5: Oral corticosteroids or Anti-IgE treatment.