Table 3.
Signaling pathways associated with differentially expressed genes
| Term | P value | ProbeName | FC (C vs NC) | FC (PC vs NC) | Gene symbol | Gene name |
|---|---|---|---|---|---|---|
| PPAR signaling pathway |
1.88E-02 |
CUST_598_PI375351158 |
2.28 |
1.33 |
FABP5 |
Fatty acid binding protein 5 (psoriasis-associated) |
| CUST_8730_PI375351158 |
1.06 |
−2.05 |
ACSL4 |
Acyl-CoA synthetase long-chain family member 4 |
||
| A_70_P058551 |
8.25 |
−1.12 |
FABP4 |
Fatty acid binding protein 4, adipocyte |
||
| A_70_P039986 |
−1.27 |
2.39 |
SLC27A2 |
Solute carrier family 27 (fatty acid transporter), member 2 |
||
| ECM-receptor interaction |
2.53E-02 |
A_70_P021711 |
−2.19 |
−1.69 |
COL1A1 |
Collagen, type I, alpha 1 |
| A_70_P058626 |
2.27 |
1.13 |
VWF |
von Willebrand factor |
||
| A_70_P016337 |
−1.78 |
−2.72 |
HMMR |
Hyaluronan-mediated motility receptor (RHAMM) |
||
| Focal adhesion | 6.73E-02 | A_70_P021711 |
−2.19 |
−1.69 |
COL1A1 |
Collagen, type I, alpha 1 |
| A_70_P058626 |
2.27 |
1.13 |
VWF |
von Willebrand factor |
||
| A_70_P050922 |
2.19 |
−1.06 |
VEGFA |
Vascular endothelial growth factor A |
||
| A_70_P031441 | −2.43 | −1.79 | VCL | Vinculin |
Signaling pathways with which differentially expressed genes (P ≤ 0.05 and ≥ 2-fold change) are associated were identified by enrichment analysis using the on-line functional annotation (DAVID Bioinformatics Resources 6.7; NIAID/NIH, USA). (C, Clinical; FC, Fold change; NC, Negative control; PC, Preclinical).