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. Author manuscript; available in PMC: 2014 Dec 23.
Published in final edited form as: Biochemistry. 2013 Dec 13;52(51):9223–9236. doi: 10.1021/bi400987k

Table 1.

Thermodynamic parameters for the binding of WW1 domain of WWOX to PPXY peptides derived from the ICD of ErbB4

Peptide Sequence Kd/μM ΔH/kcal.mol−1 TΔS/kcal.mol−1 ΔG/kcal.mol−1
ErbB4_PY1 graphic file with name nihms547377t1.jpg 383 ± 30 −6.88 ± 0.48 −2.21 ± 0.43 −4.67 ± 0.05
ErbB4_PY2 graphic file with name nihms547377t2.jpg 362 ± 45 −3.66 ± 0.33 +1.04 ± 0.40 −4.70 ± 0.07
ErbB4_PY3 graphic file with name nihms547377t3.jpg 144 ± 16 −6.21 ± 0.54 −1.24 ± 0.10 −5.25 ± 0.06

All parameters were obtained from ITC measurements at pH 7.0 and 25°C. Note that the consensus residues within the PPXY motif of each peptide are colored blue for clarity. All binding stoichiometries were fixed to unity. Errors were calculated from at least three independent measurements. All errors are given to one standard deviation.