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. Author manuscript; available in PMC: 2014 Jan 29.
Published in final edited form as: Addict Biol. 2011 Feb 11;17(2):224–234. doi: 10.1111/j.1369-1600.2010.00295.x

Figure 3. SoRI-9409 has no effect on yohimbine-induced increases in corticosterone levels in ethanol-seeking animals.

Figure 3

Plasma corticosterone (CORT) levels were increased in rats given either SoRI-9409 or SoRI-9409-vehicle prior to yohimbine (grey striped and white striped bars) compared to rats given SoRI-9409-vehicle prior to yohimbine-vehicle (white bar). Plasma CORT levels of SoRI-9409/yohimbine-vehicle treated rats (grey bar) were not different to SoRI-9409-vehicle/yohimbine-vehicle treated rats (white bar). Plasma CORT levels of SoRI-9409/yohimbine treated rats (grey striped bar) were not different to plasma CORT levels of SoRI-9409-vehicle/yohimbine treated rats (white striped bar). Rats were pretreated with SoRI-9409 (5 mg/kg I.P.) or its vehicle 30 min before yohimbine (2 mg/kg I.P.) or its vehicle. Yohimbine (or vehicle) was administered 30 min before trunk blood was collected. Data is presented as mean ± SEM (n=3 per group, each in triplicate). Statistical analysis was preformed by two-way ANOVA with Newman-Keuls post hoc testing. ** P < 0.01, compared to vehicle-vehicle group. n.s., not significant (P > 0.05).