Table 2.
Opioid-mediated [35S]GTPγS-binding stimulation in rat midbrain membranes of ethanol-trained rats administered SoRI-9409 (5 mg/kg I.P.) or vehicle prior to yohimbine (2 mg/kg I.P.) or vehicle.
| Treatment Group | Mean (± SEM) EC50 (μmol/L) for Midbrain Opioid Stimulation | |||
|---|---|---|---|---|
|
| ||||
| TAN67 | Deltorphin II | DAMGO | (−)U50488 | |
| SoRI-9409-vehicle/Yohimbine-vehicle | > 100 | > 100 | 4.1 ± 0.2 | 1.4 ± 0.3 |
| SoRI-9409-vehicle/Yohimbine | 0.14 ± 0.04*** | 27 ± 2.9 | 3.7 ± 0.2 | 1.1 ± 0.4 |
| SoRI-9409/Yohimbine-vehicle | > 100 | > 100 | 4.0 ± 0.1 | 1.6 ± 0.5 |
| SoRI-9409/Yohimbine | 5.2 ± 0.3 | 22 ± 4.0 | 4.0 ± 0.3 | 1.7 ± 0.4 |
***
P < 0.001, compared to SoRI-9409/yohimbine group