Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
TAN67-mediated [35S]GTPγS-binding stimulation in rat cerebral cortex and striatal membranes of ethanol-trained rats administered SoRI-9409 (5 mg/kg I.P.) or vehicle prior to yohimbine (2 mg/kg I.P.) or vehicle.
| Treatment Group | Mean (± SEM) EC50 (μmol/L) for TAN67 Stimulation | |
|---|---|---|
|
| ||
| Cerebral Cortex | Striatum | |
| SoRI-9409-vehicle/Yohimbine-vehicle | 6.4 ± 0.9 | > 100 |
| SoRI-9409-vehicle/Yohimbine | 21 ± 3.9 | > 100 |
| SoRI-9409/Yohimbine-vehicle | 9.4 ± 0.6 | > 100 |
| SoRI-9409/Yohimbine | 12 ± 8.3 | > 100 |
