Table 3. Secretion of Glucagon-like peptide-1 (GLP-1), Glucose-dependent insulinotropic polypeptide (GIP), insulin and glucagon and glucose disposal in NAFLD and NASH subgroups vs. controls in response to oral glucose tolerance test.
| NAFLD | NASH | NASH vs. Controls | NAFLD vs. Controls | NASH vs. NAFLD | |
| GLP-1 | |||||
| AUC (0–120 min) (pmol × min/l) | 859±78 | 888±68 | p = 0.003 | ns | ns |
| cmax (pmol/l) | 8.8±1.1 | 8.7±0.9 | p = 0.001 | ns | ns |
| GIP | |||||
| AUC (0–120 min) (pg × min/ml) | 22328±1663 | 23802±1781 | ns | ns | ns |
| cmax (pg/ml) | 262.3±24.3 | 263.7±19.5 | ns | ns | ns |
| Glucose | |||||
| AUC (0–120 min) (mmol × min/l) | 894±51 | 993±32 | p<0.001 | ns | ns |
| cmax (mmol/l) | 9.1±0.6 | 10.0±0.3 | p = 0.009 | ns | ns |
| Δ Insulin | |||||
| AUC (0–120 min) (mU × min/l) | 9209±902 | 11188±499 | p<0.001 | p = 0.003 | p = 0.054 (ns) |
| cmax (mU/l) | 116.8±8.3 | 119.9±4.3 | p<0.001 | p = 0.051 (ns) | ns |
| Glucagon | |||||
| AUC (0–120 min) (pg × min/ml) | 3986±819 | 4713±670 | p = 0.011 | ns | ns |
| cmax (pg/ml) | 56.5±10.9 | 64.9±8.2 | p<0.001 | p = 0.031 | ns |
NAFLD n = 16; NASH n = 36; controls n = 50. Data are expressed as mean±SEM. AUC, area under the curve; cmax, maximum plasma concentration. Multiple Mann-Whitney tests with Bonferroni-Holm adjustment of p-values for multiplicity of testing. P≤0.05, statistically significant difference; ns, not significant.