Table 1. RRM2 protein expression; correlation between RRM2 expression and Ki67 cell proliferation marker or clinicopathological variables.
| Patient characteristics | low (n) | high (n) | total (n) | high (%) | P |
|---|---|---|---|---|---|
| Normal epithelial tissue | |||||
| Normal ovary | 35 | 0 | 35 | 0.0% | <0.001* |
| Normal fallopian tube | 35 | 1 | 36 | 2.8% | <0.001** |
| Epithelial ovarian cancer | 59 | 46 | 105 | 43.8% | |
| Type I | 14 | 5 | 19 | 26.3% | |
| Low-grade serous | 5 | 0 | 5 | ||
| Mucinous | 3 | 0 | 3 | ||
| Low-grade endometrioid | 2 | 1 | 3 | ||
| Clear cell | 4 | 4 | 8 | ||
| Type II | 45 | 41 | 86 | 47.7% | |
| High-grade serous | 41 | 34 | 75 | ||
| High-grade endometrioid | 4 | 7 | 11 | ||
| Age | |||||
| ≤55 | 20 | 20 | 40 | 50.0% | |
| >55 | 39 | 26 | 65 | 40.0% | 0.316 |
| Ki67# | |||||
| 0–10% | 15 | 1 | 16 | 6.3% | |
| 10–40% | 14 | 5 | 19 | 26.3% | |
| 40–100% | 27 | 40 | 67 | 59.7% | <0.001 |
| Undetermined | 3 | 0 | 3 |
*Compared with epithelial ovarian cancer, P < 0.001; **Compared with high grade serous epithelial ovarian cancer, P < 0.001; #Spearman Rank Order Correlation also showed Ki67 positively corelated with RRM2 (P < 0.001, rs = 0.551).