Table 2. Association between miRSNPs and antibody responses to hepatitis B vaccine.
| miRNAs | SNP ID | Responder n = 207(%) | Mean antibody level (mIU/ml) | p value |
|---|---|---|---|---|
| MiR-196a2 | rs11614913 | 0.344 | ||
| CC | 44 (21.26) | 572.31± 313.99 | ||
| CT | 105 (50.72) | 543.06 ± 274.37 | ||
| TT | 58 (28.02) | 490.55 ± 305.24 | ||
| CT+TT | 163 (78.74) | 524.38 ± 285.91 | 0.335 (CC vs. CT+TT) | |
| CT+CC | 102 (49.28) | 525.82 ± 310.18 | 0.672 (TT vs. CT+CC) | |
| CC+TT | 149 (71.98) | 551.70 ± 285.87 | 0.177 (CT vs. CC+TT) | |
| miR-146a | rs2910164 | 0.035 | ||
| CC | 88 (42.51) | 523.84 ± 305.29 | 0.024 (CC vs. GG) | |
| CG | 92 (44.44) | 505.71 ± 285.37 | 0.011 (CG vs. GG) | |
| GG | 27 (13.04) | 667.87 ± 238.22 | ||
| CG+GG | 119 (57.49) | 542.50 ± 282.77 | 0.651 (CC vs. CG+GG) | |
| CC+GG | 115 (55.56) | 557.67 ± 296.36 | 0.204 (CG vs. CC+GG) | |
| CC+CG | 180 (86.96) | 514.57 ± 294.59 | 0.011 (GG vs. CC+CG) | |
| miR-27a | rs895819 | 0.130 | ||
| CC | 17 (8.21) | 598.83 ± 280.36 | ||
| CT | 77 (37.20) | 574.64 ± 288.77 | ||
| TT | 113 (54.59) | 497.60 ± 293.05 | ||
| CT+TT | 190 (91.79) | 528.82 ± 293.02 | 0.345 (CC vs. CT+TT) | |
| CC+TT | 130 (62.80) | 510.83 ± 292.37 | 0.129(CT vs. CC+TT) | |
| CC+CT | 94 (45.41) | 579.01 ± 285.93 | 0.046(TT vs. CC+CT) | |
| miR-149 | rs2292832 | 0.798 | ||
| CC | 20 (9.66) | 495.38 ± 286.27 | ||
| CT | 102 (49.28) | 543.37 ± 296.67 | ||
| TT | 85 (41.06) | 533.23 ± 290.24 | ||
| CT+TT | 187 (90.34) | 538.76 ± 293.02 | 0.529 (CC vs. CT+TT) | |
| CC+TT | 105 (50.72) | 526.02 ± 288.51 | 0.670(CT vs. CC+TT) | |
| CC+TT | 122 (58.94) | 535.50 ± 294.37 | 0.956 (TT vs. CC+CT) | |
| miR-124 | rs531564 | 0.709 | ||
| CC | 8 (3.86) | 549.10 ± 373.60 | ||
| CG | 54 (26.09) | 561.83 ± 333.60 | ||
| GG | 145 (70.05) | 523.61 ± 271.66 | ||
| CG+GG | 199 (96.14) | 533.98 ± 289.40 | 0.886 (CC vs. CG+GG) | |
| CC+GG | 153 (73.91) | 524.95 ± 276.36 | 0.426 (CG vs. CC+GG) | |
| CC+CG | 62 (29.95) | 560.19 ± 335.74 | 0.410 (GG vs. CG+CC) | |
| miR-26a-1 | rs7372209 | 0.303 | ||
| CC | 109 (52.66) | 562.30 ± 304.75 | ||
| CT | 85 (41.06) | 510.26 ± 270.43 | ||
| TT | 13 (6.28) | 461.01 ± 314.08 | ||
| CT+TT | 98 (47.34) | 503.73 ± 275.35 | 0.150 (CC vs. CT+TT) | |
| CC+TT | 122 (58.94) | 551.50 ± 306.04 | 0.319 (CT vs. CC+TT) | |
| CC+CT | 194 (93.72) | 539.50 ± 290.64 | 0.349 (TT vs. CC+CT) |