Table 5. Immune response in children and older adults.
| H1N1 | H3N2 | B | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GSK | Pasteur | Sinovac | p1 | GSK | Pasteur | Sinovac | p2 | GSK | Pasteur | Sinovac | p3 | |
| Children, day 7 | n = 148 | n = 74 | n = 73 | n = 148 | n = 74 | n = 73 | n = 148 | n = 74 | n = 73 | |||
| GMT | 55.9 (49.3–62.6) | 48.3 (43.4–53.4) | 32.1 (25.5–38.7) | 0.031* | 46.0 (40.3–51.6) | 38.5 (32.8–44.2) | 36.7 (30.4–43.1) | 0.342 | 15.7 (11.3–20.2) | 17.2 (12.4–22.0) | 18.9 (14.5–22.6) | 0.657 |
| SCR(%) | 48.7 (40.6–56.7) | 31.1 (20.5–41.6) | 34.3 (23.4–45.1) | 0.019† | 35.1 (27.5–42.8) | 32.4 (21.8–43.1) | 32.9 (22.1–43.7) | 0.902 | 23.0 (16.2–29.8) | 20.3 (11.1–29.4) | 26.0 (16.0–36.1) | 0.688 |
| SPR(%) | 83.8 (77.8–89.7) | 75.7 (65.9–85.4) | 74.0 (63.9–84.0) | 0.156 | 78.4 (71.7–85.0) | 74.3 (64.4–84.3) | 78.1 (68.6–87.6) | 0.780 | 45.3 (37.3–53.3) | 44.6 (33.3–55.9) | 41.1 (29.8–52.4) | 0.837 |
| Children, day 28 | n = 148 | n = 74 | n = 73 | n = 148 | n = 74 | n = 73 | n = 148 | n = 74 | n = 73 | |||
| GMT | 129.4 (117.3–141.6) | 118.5 (109.8–127.1) | 112.7 (103.6–121.9) | 0.442 | 124.7 (113.5–135.9) | 113.8 (105.9–121.7) | 119.6 (110.4–128.9) | 0.645 | 41.4 (35.7–47.2) | 38.3 (32.8–43.8) | 36.7 (30.9–42.4) | 0.322 |
| SCR(%) | 79.7 (73.3–86.2) | 70.3 (59.9–80.7) | 64.4 (53.4–75.4) | 0.098 | 72.3 (65.1–79.5) | 70.3 (59.9–80.7) | 74.0 (63.9–84.0) | 0.213 | 43.2 (35.3–51.2) | 40.5 (29.4–51.7) | 37.0 (25.9–48.1) | 0.431 |
| SPR(%) | 99.3(98.0–100.0) | 95.9(92.8–99.1) | 95.9(91.3–100.0) | 0.158 | 98.0 (95.7–100.0) | 97.3(93.6–100.0) | 97.3(93.5–100.0) | 0.926 | 73.6 (66.5–80.7) | 74.3(64.4–84.3) | 69.9(59.3–80.4) | 0.795 |
| Older adults, day 7 | n = 150 | n = 74 | n = 75 | n = 150 | n = 74 | n = 75 | n = 150 | n = 74 | n = 75 | |||
| GMT | 57.3 (50.6–64.0) | 55.6 (48.8–62.3) | 52.5 (46.2–58.8) | 0.742 | 48.9 (42.4–55.4) | 46.8 (40.3–52.2) | 48.7 (42.4–55.1) | 0.847 | 21.1 (16.2–26.0) | 19.6 (14.8–24.4) | 20.2 (15.9–24.4) | 0.652 |
| SCR(%) | 40.7 (32.8–48.5) | 36.5 (25.5–47.5) | 33.3 (22.7–44.0) | 0.544 | 36.7 (29.0–44.4) | 35.1 (24.3–46.0) | 32.0 (21.4–42.6) | 0.478 | 22.7 (16.0–29.4) | 21.6 (12.2–31.0) | 21.3 (12.1–30.6) | 0.063 |
| SPR(%) | 72.0 (64.8–79.2) | 68.9 (58.4–79.5) | 66.7 (56.0–77.3) | 0.697 | 68.7 (61.2–76.1) | 67.6 (56.9–78.2) | 68.0 (57.4–78.6) | 0.985 | 34.7 (27.1–42.3) | 35.1 (24.3–46.0) | 33.3 (22.7–43.1) | 0.970 |
| Older adults, day 28 | n = 150 | n = 74 | n = 75 | n = 150 | n = 74 | n = 75 | n = 150 | n = 74 | n = 75 | |||
| GMT | 126.2 (119.7–132.7) | 116.4 (109.6–123.3) | 108.3 (99.9–116.6) | 0.546 | 112.5 (106.3–118.6) | 119.4 (112.5–126.2) | 117.9 (106.8–128.0) | 0.627 | 42.2(37.4–47.0) | 37.1 (31.4–42.8) | 36.8 (30.8–42.9) | 0.421 |
| SCR(%) | 65.3 (57.7–73.0) | 63.5 (52.5–74.5) | 62.7 (51.7–73.6) | 0.916 | 62.7 (54.9–70.4) | 60.8 (49.7–71.9) | 60.0 (48.9–71.1) | 0.917 | 43.3 (35.4–51.3) | 41.9 (30.7–53.1) | 38.7 (27.7–49.7) | 0.448 |
| SPR(%) | 93.3 (89.3–97.3) | 94.6 (89.4–99.7) | 89.3 (82.3–96.3) | 0.422 | 91.3 (86.8–95.8) | 90.5 (83.9–97.2) | 86.7 (79.0–94.4) | 0.537 | 72.0 (64.8–79.2) | 68.9 (58.4–79.5) | 69.3 (58.9–79.8) | 0.861 |
GMT, geometric mean titer; SCR, seroconversion rate; SPR, seroprotection rate; p1, p1, p3, p values by comparing the responses among the three arms to H1N1, H3N1 and B antigens, respectively. Data in parentheses are 95% CI. *GSK vs. Pasteur: p = 0.417; GSK vs. Sinovac: p = 0.024; Pasteur vs. Sinovac: p = 0.039. †GSK vs. Pasteur: p = 0.013; GSK vs. Sinovac: p = 0.042; Pasteur vs. Sinovac: p = 0.682. α’ = α/m = 0.05/3 = 0.017 according to Bonferroni adjustment.