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. 2014 Feb 14;25(3):177–183. doi: 10.1097/WNR.0000000000000069

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© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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Fig. 6 — Model of the PTEN/PI3K/Akt-signaling pathway for regulating the proliferation and differentiation of auditory progenitors. PI3K phosphorylates PIP2, converting PIP2 into PIP3. Conversely, PTEN dephosphorylates PIP3, converting PIP3 back into PIP2. PIP3 directly phosphorylates Akt to generate p-Akt. P-Akt phosphorylates p27^kip1 and triggers its degradation. The p27^kip1 level maintains ZNPCs in the nonproliferative state. Downregulation of p27^kip1 induces the differentiation of progenitors at ZNPC into HCs. Thus, PTEN may regulate the proliferation and differentiation of auditory progenitors through p-Akt and p27^kip1. HCs, hair cells; ZNPCs, zone of nonproliferating cells.