Figure 1. (A) Proposed model of Bmf tethering the Beclin1/Bcl-2 complex to the Myosin V by binding DLC2. In resting cells, Bmf binds to the Beclin1/Bcl-2 complex and maybe to DLC2, thereby linking the autophagy complex to myosin V, to inhibit autophagy initiation. (B) Bim tethers Beclin1 to the Dynein motor complex by binding DLC1. In resting cells, Bim binds to DLC1 and to Beclin1, and probably to the Beclin1/Bcl2 complex, and thereby links them to the dynein motor complex to inhibit autophagy initiation.