Table 1. Metabolic findings.
Untreated | Pulsed | Prolonged | |||||||
---|---|---|---|---|---|---|---|---|---|
(n = 10) | (n = 10) | (n = 10) | |||||||
Whole body | |||||||||
Animal weight (grams) | 24.21 | ± | 2.12 | 23.48 | ± | 2.61 | 22.89 | ± | 2.4 |
Serum glucose level (mM L−1) | 7.1 | ± | 2.22 | 7.5 | ± | 1.72 | 6.93 | ± | 2.34 |
Whole body FDG clearance (mL X min−1) | 0.24 | ± | 0.08 | 0.27 | ± | 0.10 | 0.14 | ± | 0.07* |
Whole body glucose consumption (µM X min−1) | 1.73 | ± | 0.93 | 1.78 | ± | 0.78 | 1.22 | ± | 0.23* |
Cancer lesion | |||||||||
Animals with palpable tumor | 10 | 9 | 7 | ||||||
Tumor weight (mg) | 366 | ± | 133 | 353 | ± | 146 | 233 | ± | 105* |
Tumor volume at PET (µL) | 306 | ± | 93 | 306 | ± | 125 | 187 | ± | 89* |
Tumor glucose consumption (nM X min−1 X g−1) | 79.5 | ± | 14 | 74.9 | ± | 29 | 41.64 | ± | 5.5* |
Total lesion glucose consumption (nM) | 24.33 | ± | 4.87 | 22.92 | ± | 5.21 | 7.79 | ± | 1.87 |
FDG uptake (SUV mean) | 1.16 | ± | 0.09 | 1.14 | ± | 0.08 | 1.09 | ± | 0.04 |
FDG uptake (SUV max) | 2.32 | ± | 0.48 | 2.26 | ± | 0.76 | 2.11 | ± | 0.71 |