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Reconstitution of human liver structures from differentiated HepaRG® cells in vivo. Hepatocyte-like colonies (upper panel) and biliary-like colonies (lower panel) in a TK-NOG mouse liver that was transplanted with differentiation D35 HepaRG® cells were subjected to immunohistochemical analysis. Serial liver sections were stained for H&E, HLA, hAlb and CK-19. Bar = 100 μm.
