Table 2.
Engraftment of cryopreserved human hepatocytes in TK-NOG livers.
| Cryopreservedhepatocytes | Mouse ID No. | BW (g) | hAlb (μg/mL) | RI (%) |
|---|---|---|---|---|
| HEP187170 | 73 | 24.7 | 1459 | 20.9 |
| 78 | 27.5 | 684 | 12.0 | |
| 79 | 27.9 | 1061 | 16.3 | |
| 712 | 21.0 | 2778 | 36.0 | |
| HEP187170 | 714 | 18.6 | 2818 | 36.4 |
| 102 | 22.0 | 4803 | 59.1 | |
| 113 | 21.5 | 3355 | 42.6 | |
| 114 | 20.6 | 5115 | 62.7 |
The amount of hAlb and extent of human liver reconstitution in TK-NOG mice were measured 12 weeks after transplantation of cryopreserved human hepatocytes (HEP187170). BW: body weight. The extent of human liver reconstitution was estimated as a function of the hAlb concentration, which was shown to correlate with the extent of human liver reconstitution. RI: reconstitution index.