Table 2.
Factors associated with one-year mortalitya
| Univariableb | Final modelc | |||||
|---|---|---|---|---|---|---|
| Dead (n=100) | Alive (n=467) | HR (95% CI) | p | HR (95% CI) | p | |
| ART (time dependent) | – | – | 0.39 (0.25–0.60) | <0.001 | 0.44 (0.27–0.71) | 0.001 |
| Positive cryptococcal Ag (%) | 13.0 | 4.1 | 2.57 (1.43–4.60) | 0.002 | 2.19 (1.78–4.06) | 0.013 |
| Male sex (%) | 72.0 | 78.4 | 0.74 (0.48–1.15) | 0.181 | – | – |
| Age in years, median | 31 | 30 | 1.02 (0.99–1.05) | 0.261 | – | – |
| CD4 cells/μL, median | 11 | 23 | 0.98 (0.98–1.00) | 0.004 | – | – |
| WHO stage 4 (%) | 82.0 | 58.4 | 2.81 (1.37–5.79) | 0.007 | 2.28 (1.17–4.43) | 0.017 |
| HIV-RNA in log/mL, median | 5.45 | 5.16 | 2.34 (1.21–4.53) | 0.011 | – | – |
| Anaemiad (%) | 83.0 | 63.5 | 2.59 (1.53–4.37) | <0.001 | – | – |
| Oral candidiasis (%) | 66.0 | 52.0 | 2.50 (1.54–4.05) | <0.001 | 2.26 (1.38–3.65) | 0.001 |
| Cerebral toxoplasmosis (%) | 13.0 | 8.7 | 1.25 (0.93–1.69) | 0.445 | – | – |
| TB at admission (%) | 17.0 | 19.4 | 0.76 (0.85–0.99) | 0.300 | – | – |
a
This table excludes those who were lost to follow-up. Cox regression was performed using pooled data from multiple imputations. Data were missing for anaemia (n=8), candidiasis (n=56), WHO clinical stage (n=115). BMI (n=115), HIV-RNA (n=473).
b
Variables with p>0.100 were not included in multivariable analysis.
c
HIV-RNA and BMI were not included in the final model because of the many missing values. Candidiasis was not included in the final model because of the possible interaction with WHO stage.
d
Anaemia was defined as<11.0 g/dL for female and<13.0 g/dL for male.