Table 3.
Cox regression analysis of composite end point death and loss to follow-up in one yeara
| Univariableb | Final modelc | |||||
|---|---|---|---|---|---|---|
| Dead or lost to FU n=343 | Alive n=467 | HR (95% CI) | p | HR (95% CI) | p | |
| ART (time dependent) | – | – | 0.24 (0.19–0.31) | <0.001 | 0.24 (0.19–0.32) | <0.0001 |
| Positive cryptococcal Ag (%) | 11.4 | 4.1 | 2.05 (1.47–2.86) | <0.001 | 1.57 (1.12–2.20) | 0.009 |
| Age in year, median | 30 | 30 | 1.01 (1.00–1.03) | 0.084 | – | – |
| Male sex (%) | 78.2 | 78.4 | 0.81 (0.64–1.03) | 0.090 | 0.75 (0.59–0.96) | 0.022 |
| CD4 cell count, median | 15 | 23 | 0.99 (0.99–1.00) | <0.001 | 0.99 (0.99–1.00) | 0.002 |
| WHO stage 4 (%) | 74.9 | 58.4 | 1.79 (1.27–2.51) | 0.002 | 1.62 (1.16–2.28) | 0.007 |
| HIV-RNA in log/mL, median | 5.39 | 5.08 | 1.78 (1.18–2.70) | 0.006 | – | – |
| Anaemiad (%) | 76.4 | 63.5 | 1.65 (1.28–2.13) | <0.001 | 1.46 (1.13–1.91) | 0.004 |
| BMI in kg/m2, median | 17.19 | 18.08 | 1.49 (1.10–2.02) | 0.011 | – | – |
| Oral candidiasis (%) | 63.3 | 52.0 | 1.41 (1.11–1.78) | 0.004 | – | – |
| Cerebral toxoplasmosis (%) | 8.2 | 10.1 | 0.77 (0.64–0.94) | 0.195 | – | – |
| TB at admission (%) | 14.6 | 22.5 | 0.65 (0.48–0.88) | 0.005 | 0.61 (0.45–0.83) | 0.002 |
a
Cox regression was performed using pooled data from multiple imputations. Data were missing for anaemia (n=8), candidiasis (n=56), WHO clinical stage (n=115). BMI (n=115), HIV-RNA (n=473).
b
Variables with p>0.100 were not included in multivariable analysis.
c
Plasma HIV-RNA was not included in the final model because of the many missing values.
d
Anaemia was defined as<11.0 g/dL for female and<13.0 g/dL for male.