Table 3.
Clinical signs and symptoms according to the main sites of fungal infection
| Sign/symptom | HAEs (n = 113) |
Non-HAEs (n = 119) |
All patients (n = 232) |
|---|---|---|---|
| Pulmonary localization, n (%) | 94 | 89 | 183 |
| Fever | 73 (77.6) | 54 (60.7) | 127 (69.4) |
| Dyspnea | 28 (29.8) | 43 (48.3) | 71 (38.8) |
| Cough | 16 (17.0) | 30 (33.7) | 46 (25.1) |
| Chest Pain | 11 (11.7) | 10 (11.2) | 21 (11.5) |
| Hemoptysis | 7 (7.4) | 6 (6.7) | 13 (7.1) |
| Blood, n (%) | 10 | 6 | 16 |
| Fever | 9 (90.0) | 4 (66.7) | 13 (81.2) |
| Orbito-sinus localization, n (%) | 8 | 8 | 16 |
| Fever | 7 (87.5) | 4 (50.0) | 11 (68.7) |
| Facial pain/edema/palsy | 5 (62.5) | 1 (12.5) | 6 (37.5) |
| Headache | – | 3 (37.5) | 3 (18.7) |
| Orbital cellulitis | 1 (12.5) | 2 (25.0) | 3 (18.7) |
| Necrotic lesions | 2 (25.0) | 1 (12.5) | 3 (18.7) |
| Ophthalmoplegia/Rhinorrhea | 2 (25.0) | 1 (12.5) | 3 (18.7) |
| Central nervous system involvement, n (%) | 8 | 5 | 13 |
| Fever | 8 (100.0) | 2 (40.0) | 10 (76.9) |
| Headache | 2 (25.0) | 2 (40.0) | 4 (30.7) |
| Blurred/double vision | 2 (25.0) | 2 (40.0) | 4 (30.7) |
| Apathy/confusion | – | 2 (40.0) | 2 (15.3) |
| Facial palsy/ophthalmoplegia | 2 (25.0) | 1 (20.0) | 3 (23.1) |
| Skin and soft tissue involvement, n (%) | 7 | 5 | 12 |
| Lesion (papule, vesicle, ulcer, necrosis) | 3 (42.8) | 5 (100.0) | 8 (66.7) |
| Fever | 3 (42.8) | 2 (40.0) | 5 (41.7) |
| Pain | 1 (14.3) | 2 (40.0) | 3 (25.0) |
| Hypothermia | – | 1 (20.0) | 1 (8.3) |
| Eye involvement, n (%) | 0 | 10 | 10 |
| Pain | – | 7 (70.0) | 7 (70.0) |
| Hypopyon | – | 5 (50.0) | 5 (50.0) |
| Photophobia | – | 3 (30.0) | 3 (30.0) |
| Corneal ulcer | – | 2 (20.0) | 2 (20.0) |
| Eyelid swelling | – | 2 (20.0) | 2 (20.0) |
| Fever | – | 1 (10.0) | 1 (10.0) |
| Abdominal involvement, n (%) | 4 | 3 | 7 |
| Pain/diarrhea | 4 (100.0) | 3 (100.0) | 7 (71.4) |
| Fever | 3 (75.0) | 2 (66.7) | 5 (71.4) |
| Asymptomatic patients, n (%) | – | 3 | 3 |
HAEs hematological patients, non-HAE non-hematological patients