Table 2.
Footprint sequences in DH and JH alleles.
| DH gene | Sequence (footprint(s) in red font) |
|---|---|
| D1-1*01 | GGTACAACTGGAACGAC |
| D1-14*01 | GGTATAACCGGAACCAC |
| D1-20*01 | GGTATAACTGGAACGAC |
| D1-26*01 | GGTATAGTGGGAGCTACTAC |
| D1-7*01 | GGTATAACTGGAACTAC |
| D2-15*01 | A TGTAGTGGTGGTAGCTGCTACTCC |
| D2-2*01 | ATGTAGTAGTACCAGCTGCTATGCC |
| D2-2*02 | ATGTAGTAGTACCAGCTGCTATACC |
| D2-2*03 | TTGTAGTAGTACCAGCTGCTATGCC |
| D2-21*01 | AGCATATTGTGGTGGTGATTGCTATTCC |
| D2-21*02 | AGCATATTGTGGTGGTGACTGCTATTCC |
| D2-8*01 | ATGTACTAATGGTGTATGCTATACC |
| D2-8*02 | ATGTACTGGTGGTGTATGCTATACC |
| D3-10*01 | GTATTACTATGGTTCGGGGAGTTATTATAAC |
| D3-10*02 | GTATTACTATGTTCGGGGAGTTATTATAAC |
| D3-16*01 | GTATTATGATTACGTTTGGGGGAGTTATGCTTATACC |
| D3-16*02 | GTATTATGATTACGTTTGGGGGAGTTATCGTTATACC |
| D3-22*01 | GTATTACTATGATAGTAGTGGTTATTACTAC |
| D3-3*01 | GTATTACGATTTT TGGTTATTATACC |
| D3-3*02 | GTATTAGCATTTTTGGTTATTATACC |
| D3-9*01 | GTATTAC TTTGACTGGTTATTATAAC |
| D4-11*01 | TGACTACAGTAACTAC |
| D4-17*01 | TGAC TGACTAC |
| D4-23*01 | TGACTGGTAACTCC |
| D4-4*01 | TGACTACAGTAACTAC |
| D5-12*01 | GT GTGGCTACGATTAC |
| D5-18*01 | GT AGCTATGGTTAC |
| D5-24*01 | G GGCTACAATTAC |
| D5-5*01 | GT AGCTATGGTTAC |
| D6-13*01 | GGGTATAGCAGCAGCTGGTAC |
| D6-19*01 | GGGTATAGCAGTGGCTGGTAC |
| D6-25*01 | GGGTATAGCAGCGGCTAC |
| D6-6*01 | GAGTATAGCAGCTCGTCC |
| D7-27*01 | CTAACTGGGGA |
| JH gene | Sequence (footprint(s) in red font) |
| J1*01 | GCTGAATACTTCCAGCACTGGGGCCAGGGCACCCTGGTC ACCGTCTCCTCAG |
| J2*01 | CTACTGGTACTTCGATCTCTGGGGCCGTGGCACCCTGGTC ACTGTCTCCTCAG |
| J3*01 | TGATGCTTTTGATGTCTGGGGCCA CAATGGTCACCG TCTCTTCAG |
| J3*02 | TGATGCTTTTGATATCTGGGGCCACAATGGTCACCG TCTCTTCAG |
| J4*01 | ACTACTTTGACTACTGGGGCCAAGGAACCCTGGTCACCGTCT CCTCAG |
| J4*02 | ACTACTTTGACTACTGGGGCCACCCTGGTCACCGTCT CCTCAG |
| J4*03 | GCTACTTTGACTACTGGGGCCACCCTGGTCACCGTCT CCTCAG |
| J5*01 | ACAACTGGTTCGACTCCTGGGGCCAAGGAACCCTGGTCACC GTCTCCTCAG |
| J5*02 | ACAACTGGTTCGACCCCTGGGGCC ACCCTGGTCACCGTCTCCTCAG |
| J6*01 | ATTACTACTACTAC CCACGGTCACCGTCTCCTCAG |
| J6*02 | ATTACTACTACTAC CCACGGTCACCGTCTCCTCAN |
| J6*03 | ATTACTACTACTACTACTA CCACGGTCACCGTCTCCTCAN |
| J6*04 | ATTACTACTACTAC CCACGGTCACCGTCTCCTCAG |
Thirty-four germline functional human DH alleles and 13 JH alleles were downloaded from the IMGT database (54). Each allele was scanned for all of the possible five nucleotide footprint motifs listed in Table 1. Sequences containing five nucleotide footprints are given in red font. In some cases the region matches more than one possible footprint (for example, D5-12*01 contains three different footprints: GGATA, GATAT, and ATATA).